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Year Number of Results
1988 1
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1993 5
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1998 9
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2002 9
2003 4
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267 results

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Page 1
Lipid-anchored proteasomes control membrane protein homeostasis.
Zhang R, Pan S, Zheng S, Liao Q, Jiang Z, Wang D, Li X, Hu A, Li X, Zhu Y, Shen X, Lei J, Zhong S, Zhang X, Huang L, Wang X, Huang L, Shen L, Song BL, Zhao JW, Wang Z, Yang B, Guo X. Zhang R, et al. Sci Adv. 2023 Dec;9(48):eadj4605. doi: 10.1126/sciadv.adj4605. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019907 Free PMC article.
Protein degradation in eukaryotic cells is mainly carried out by the 26S proteasome, a macromolecular complex not only present in the cytosol and nucleus but also associated with various membranes. ...These findings have defined an evolutionarily conserved mechanism for ma …
Protein degradation in eukaryotic cells is mainly carried out by the 26S proteasome, a macromolecular complex not only present in the …
Lipid-anchored Proteasomes Control Membrane Protein Homeostasis.
Zhang R, Pan S, Zheng S, Liao Q, Jiang Z, Wang D, Li X, Hu A, Li X, Zhu Y, Shen X, Lei J, Zhong S, Zhang X, Huang L, Wang X, Huang L, Shen L, Song BL, Zhao J, Wang Z, Yang B, Guo X. Zhang R, et al. bioRxiv [Preprint]. 2023 May 12:2023.05.12.540509. doi: 10.1101/2023.05.12.540509. bioRxiv. 2023. PMID: 37214852 Free PMC article. Updated. Preprint.
Protein degradation in eukaryotic cells is mainly carried out by the 26S proteasome, a macromolecular complex not only present in the cytosol and nucleus but also associated with various membranes. ...These findings have defined an evolutionarily conserved mechanism for ma …
Protein degradation in eukaryotic cells is mainly carried out by the 26S proteasome, a macromolecular complex not only present in the …
Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins: perspectives from protein-lipid interactions (Review).
Marsh D, Horváth LI, Swamy MJ, Mantripragada S, Kleinschmidt JH. Marsh D, et al. Mol Membr Biol. 2002 Oct-Dec;19(4):247-55. doi: 10.1080/09687680210162419. Mol Membr Biol. 2002. PMID: 12512771 Review.
Studies of lipid-protein interactions in double-reconstituted systems involving both integral and peripheral or lipid-anchored proteins are reviewed. Membranes of dimyristoyl phosphatidylglycerol containing either myelin proteolipid protein or c …
Studies of lipid-protein interactions in double-reconstituted systems involving both integral and peripheral or lipid-ancho …
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.
Kauffman KJ, Dorkin JR, Yang JH, Heartlein MW, DeRosa F, Mir FF, Fenton OS, Anderson DG. Kauffman KJ, et al. Nano Lett. 2015 Nov 11;15(11):7300-6. doi: 10.1021/acs.nanolett.5b02497. Epub 2015 Oct 20. Nano Lett. 2015. PMID: 26469188
Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein production for many therapeutic applications. Although lipid nanoparticles have shown considerable promise for the delivery of small interfering RNAs (siRNA), their utility as agents for mRN …
Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein production for many therapeutic applications. Alth …
Use of a Liver-Targeting Immune-Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut-Induced Anaphylaxis by Single- and Multiple-Epitope Nucleotide Sequence Delivery.
Xu X, Wang X, Liao YP, Luo L, Xia T, Nel AE. Xu X, et al. ACS Nano. 2023 Mar 14;17(5):4942-4957. doi: 10.1021/acsnano.2c12420. Epub 2023 Feb 28. ACS Nano. 2023. PMID: 36853930 Free PMC article.
Codon-optimized mRNA was used for microfluidics synthesis of LNPs with an ionizable cationic lipid, also decorated with a lipid-anchored mannose ligand for LSEC targeting. Biodistribution to the liver was confirmed by in vivo imaging, while ELISpot assays demonstrat …
Codon-optimized mRNA was used for microfluidics synthesis of LNPs with an ionizable cationic lipid, also decorated with a lipid-an …
Lipid-anchored drugs for delivery into subcellular compartments.
Rajendran L, Udayar V, Goodger ZV. Rajendran L, et al. Trends Pharmacol Sci. 2012 Apr;33(4):215-22. doi: 10.1016/j.tips.2012.01.006. Epub 2012 Mar 3. Trends Pharmacol Sci. 2012. PMID: 22385603 Review.
Although most drug targets are localized within intracellular compartments, specific targeting of drugs at the subcellular level is not well established. Membrane proteins, lipids, nutrients and some pathogens are internalized into the cell to be targeted to distinct subce …
Although most drug targets are localized within intracellular compartments, specific targeting of drugs at the subcellular level is not well …
Incorporation of Artificial Lipid-Anchored Proteins into Cultured Mammalian Cells.
Leventis R, Silvius JR. Leventis R, et al. Methods Mol Biol. 2017;1609:241-253. doi: 10.1007/978-1-4939-6996-8_20. Methods Mol Biol. 2017. PMID: 28660587
Exogenous lipid-anchored proteins can be incorporated into the plasma membranes of living mammalian cells, allowing the chemical structure of the incorporated protein and its lipid anchor to be controlled (and varied) to a much greater degree than is p …
Exogenous lipid-anchored proteins can be incorporated into the plasma membranes of living mammalian cells, allowing the …
Deciphering lipid codes: K-Ras as a paradigm.
Zhou Y, Hancock JF. Zhou Y, et al. Traffic. 2018 Mar;19(3):157-165. doi: 10.1111/tra.12541. Epub 2017 Dec 10. Traffic. 2018. PMID: 29120102 Free PMC article. Review.
Although the biophysical processes governing lipid lateral segregation in the cell PM have been established in vitro, biological implications of lipid heterogeneity are poorly understood. Of particular interest is how membrane proteins potentially utilize transient spatial …
Although the biophysical processes governing lipid lateral segregation in the cell PM have been established in vitro, biological implication …
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.
Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB. Chang CW, et al. J Biol Chem. 2016 Feb 5;291(6):2848-57. doi: 10.1074/jbc.M115.701169. Epub 2015 Dec 8. J Biol Chem. 2016. PMID: 26663078 Free PMC article.
SNARE proteins catalyze many forms of biological membrane fusion, including Ca(2+)-triggered exocytosis. ...Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2 to a membrane by a TMD greatly improves its function. ...
SNARE proteins catalyze many forms of biological membrane fusion, including Ca(2+)-triggered exocytosis. ...Thus, lipid-anc …
Greasing their way: lipid modifications determine protein association with membrane rafts.
Levental I, Grzybek M, Simons K. Levental I, et al. Biochemistry. 2010 Aug 3;49(30):6305-16. doi: 10.1021/bi100882y. Biochemistry. 2010. PMID: 20583817 Review.
An example is membrane rafts, which are lipid-mediated domains dependent on preferential association between sterols and sphingolipids and inclusive of a specific subset of membrane proteins. While the lipid and protein composition of rafts has been extensively char …
An example is membrane rafts, which are lipid-mediated domains dependent on preferential association between sterols and sphingolipids and i …
267 results